Embryo‐Fetal Developmental Toxicity Studies with Pregabalin in Mice and Rabbits
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چکیده
منابع مشابه
Historical control data on prenatal developmental toxicity studies in rabbits.
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits wer...
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متن کاملThe developmental toxicity of boric acid in mice, rats, and rabbits.
Boric acid (BA) is a naturally occurring agent used in manufacturing processes and numerous consumer products. Because of the potential for both industrial and consumer exposure to boron-containing compounds, and the lack of developmental toxicity data, the National Toxicology Program evaluated the potential for boric acid to cause developmental toxicity in pregnant Swiss (CD-1) mice, Sprague-D...
متن کاملTeratogenic Effects of Pregabalin in Mice
Objective(s): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied. Materials and Methods: Timed-pregnant mice received one of three doses of PGB (20, 40 or 80 mg/kg/day) or the vehicl...
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ژورنال
عنوان ژورنال: Birth Defects Research Part B: Developmental and Reproductive Toxicology
سال: 2016
ISSN: 1542-9733,1542-9741
DOI: 10.1002/bdrb.21174